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ESSAY: Benchmark – Part A: Population Health Research and PICOT Statement

The topic I would like to write about would be the use of Ryanodex versus Dantrolene for Malignant Hyperthermia in the Ambulatory Surgical Setting, even though more expensive, with minimal staffing, the outcomes would be more favorable. Here are the assignment instructions below:

In this course, you will be complete a 2-part assignment in which you conduct research about a population of focus, develop a PICOT statement, and write a Literature Review. The PICOT statement and Literature Review you write in this course can be used for your evidence-based practice project in the next course so be sure to select an issue you want to continue working on in your next course.
PICOT (Population/Problem, Intervention, Comparison, Outcome, and Time to achieve the outcome) is a method that helps clarify the qualities needed to create a good question out of a practice issue or problem affecting the population of focus. Additionally, the information derived from a good PICOT makes it easier to perform a literature search in order to find translational research sources that can be used to address the clinical problem.
Use a national, state or local population health care database to research indicators of disparity. Choose a mortality/morbidity indicator to identify a clinical problem or issue that you want to explore pertaining to a population of focus. Use this indicator to begin to formulate a PICOT and conduct research on the population.
Write a 750-1,000-word paper that analyzes your research and focuses on the population you have chosen. Describe the population’s demographics and health concerns, and explain how nursing science, health determinants, and epidemiologic, genomic, and genetic data may impact population health management for the selected population. Provide an overview of a potential solution for solving the health issue related to your population and the intended PICOT statement. Describe how the solution incorporates health policies and goals that support health care equity for the population of focus.


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Malignant hyperthermia is an inherited disorder that is life threatening and is triggered by drugs which are administered during general anesthesia. A person experiencing malignant hyperthermia would have symptoms such as a drastic increase in body temperature as well as muscle contractions that could be very severe (Greig & Jones, 2013). Susceptible patients may succumb as they undergo surgery since they cannot be easily resuscitated. The situation is particularly critical in ambulatory care settings. It calls for proper medication to ensure that the susceptible patients respond not only positively but also in time.

 The most common antidotes used for this purpose are Ryanodex and Dantrolene. This essay seeks to respond to a PICOT question that analyzes the effectiveness of Rynadex over Dantrolene based on critical literature review. The paper will show that Rynadex though expensive, it always presents more favorable outcomes in ambulatory care settings.

PICOT Question

P: Population –  Susceptible young patients

I: Intervention – Administering of Ryanodex

C: Comparison – Use of Ryanodex in comparison to Dentrolene in Ambulatory surgical setting

O: Outcome- Effective control of Malignant Hyperthermia

T: Time – preoperative and recovery time.”

Literature Review There are many documented advantages of Ryanodex versus Dantrolene depending on the age of the susceptible patient. First, Benson (2016) indicates that Ryanodex uses significantly less volumes of sterile water during injection hence less periods of time is needed for administration. For instance, while Ryanodex requires two minutes, many formulations of dantrolene may need more than 20 minutes for them to be administered (Benson, 2016). For a young patient having weight of 10kg for example, the required dosage of Ryanodex is 25.0mg, the number of vials is one and volume of sterile water for reconstitution is only 5ml. On the contrary, a similar patient would require two vials and 120 ml of sterile water will b…

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